ParkinsonCanadaV1, Main, Exploration, bibRecord, 001950

Electroconvulsive Therapy Alters Dopamine Signaling in the Striatum of Non-human Primates

Identifieur interne : 001950 ( Main/Exploration ); précédent : 001949; suivant : 001951

Electroconvulsive Therapy Alters Dopamine Signaling in the Striatum of Non-human Primates

Auteurs : Anne M. Landau [Danemark, Canada] ; M. Mallar Chakravarty [Danemark, Canada] ; Campbell M. Clark [Canada] ; Athanasios P. Zis [Canada] ; Doris J. Doudet [Danemark, Canada]

Source :

Neuropsychopharmacology : (New York, NY) [ 0893-133X ] ; 2011.

RBID : Pascal:11-0163742

Descripteurs français

Pascal (Inist)
- Electroconvulsivothérapie, Dopamine, Transduction signal, Corps strié, Singe, Récepteur dopaminergique, Transporteur de la dopamine, Transporteur vésiculaire de monamine, Transporteur vésiculaire monoamine.
Wicri :
- topic : Singe.

English descriptors

KwdEn :
- Corpus striatum, Dopamine, Dopamine receptor, Electroconvulsive therapy, Monkey, Signal transduction, Vesicular monoamine transporter.

Abstract

Electroconvulsive therapy (ECT) is one of the most effective therapies for depression and has benefcial motor effects in parkinsonian patients. However, little is known about the mechanisms of therapeutic action of ECT for either condition. The aim of this work was to explore the impact of ECT on dopaminergic function in the striatum of non-human primates. Rhesus monkeys underwent a course of six ECT treatments under a human clinical protocol. Longitudinal effects on the dopaminergic nigrostriatal system were studied over 6 weeks using the in vivo capabilities of positron emission tomography (PET). PET scans were performed prior to the onset of ECT treatments and at 24-48 h, 8-10 days, and 6 weeks after the final ECT treatment. Early increases in dopamine transporter and vesicular monoamine transporter 2 binding returned to baseline levels by 6 weeks post-ECT. Transient increases in D1 receptor binding were also observed, whereas the binding potential to D2 receptors was unaltered. The increase in dopaminergic neurotransmission suggested by our results may account in part for the therapeutic effect of ECT in mood disorders and Parkinson's disease.

Affiliations:

Canada, Danemark

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Le document en format XML

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<front><div type="abstract" xml:lang="en">Electroconvulsive therapy (ECT) is one of the most effective therapies for depression and has benefcial motor effects in parkinsonian patients. However, little is known about the mechanisms of therapeutic action of ECT for either condition. The aim of this work was to explore the impact of ECT on dopaminergic function in the striatum of non-human primates. Rhesus monkeys underwent a course of six ECT treatments under a human clinical protocol. Longitudinal effects on the dopaminergic nigrostriatal system were studied over 6 weeks using the in vivo capabilities of positron emission tomography (PET). PET scans were performed prior to the onset of ECT treatments and at 24-48 h, 8-10 days, and 6 weeks after the final ECT treatment. Early increases in dopamine transporter and vesicular monoamine transporter 2 binding returned to baseline levels by 6 weeks post-ECT. Transient increases in D1 receptor binding were also observed, whereas the binding potential to D2 receptors was unaltered. The increase in dopaminergic neurotransmission suggested by our results may account in part for the therapeutic effect of ECT in mood disorders and Parkinson's disease.</div>
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	La maladie de Parkinson au Canada (serveur d'exploration)
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Electroconvulsive Therapy Alters Dopamine Signaling in the Striatum of Non-human Primates

Electroconvulsive Therapy Alters Dopamine Signaling in the Striatum of Non-human Primates

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri